I have driven to Ayacucho on the Libertador highway. Surfaces were just fine. Just be careful with the hairpin turns. Went to Huancavelica once by car from Huancayo 8 years ago. Road was brand new and perfect. Also went by bus from Lima to Ayacucho. I forget the line, but it stopped in Ica.
"Hay que distanciarnos hoy para luego abrazarnos más fuerte".
-Guiseppe Conte, primer ministro italiano.